[北京]中国科学院生物物理研究所欧光朔课题组招聘

发布时间：2010-04-08
工作地点：北京
信息来源：东南大学
职位类型：全职
职位描述
中国科学院生物物理研究所欧光朔课题组招聘启事

中国科学院生物物理研究所欧光朔课题组现因工作需要公开招聘研究人员。本课题组发展***荧光时序成像技术并结合生物化学和遗传学，以线虫为模型着重研究细胞骨架和信号转导蛋白如何调控神经母细胞的迁移、不对称分裂及凋亡。

一、招聘岗位要求：

1、副研究员或助理研究员：具有相关领域博士学位，并发表过高质量科研论文；具有独立 科研工作能力，能够独立申报科研经费。

2、博士后：近期或即将获得相关领域博士学位，并发表过科研论文；具有相对独立科研工作能力，能独立申报博士后/青年基金。

3、研究实习员：具有生命科学相关专业本科或硕士学位，受过良好的科研训练。

4、业务秘书：具有生命科学相关专业本科或硕士学位，要求具有较好的英语水平、组织协调和文字表达能力。

二、招聘办法及要求：

请符合条件的申请者将个人简历、代表性论文、研究计划和至少两位推荐人的姓名及联系方式发至：gou (AT) 〔请将(AT)替换为@，防止垃圾邮件〕。邮件主题内请注明应聘岗位。

简历欧光朔研究员

Guangshuo Ou, Professor

简历：

2010- 中国科学院生物物理研究所，“百人计划”研究员，博士生导师

2007-2010 美国加利福尼亚州大学旧金山分校/霍华德休斯医学研究院 (HHMI)，博士后
2001-2006 美国加利福尼亚州大学戴维斯分校，获细胞和发育生物学博士学位
1994-2001 中国农业大学生物学院，获理学学士、硕士学位

Biography & Introduction

2010- Professor, Institute of Biophysics, Chinese Academy of Sciences

2007-2010 University of California, San Francisco/ Howard Hughes Medical Institute, Damon Runyon Postdoctoral Research Fellow (Advisor: Dr. Ron Vale)
2001-2006 Ph.D. Cell & Developmental Biology, University of California,Davis; The Norton B. Gilula Award from the American Society for Cell Biology in 2005 (Advisor: Dr. Jonathan M. Scholey)

1994-2001 B.S.& M.S. China Agricultural University, College of Biological Sciences, (Advisor: Dr. Ming Yuan)

Selected publication

1. Ou, G., D'Ambrosio, M and R.D. Vale. Polarized Myosin Produces Unequal Size Daughters during Asymmetric Cell Division. submitted

2. Ou, G. and R.D. Vale (2009) Molecular signatures of cell migration in C. elegans Q neuroblasts. Journal of Cell Biology. 185: 77-85.

3. Snow, J*, Ou, G.*, Gunnarson, A, Walker, R, Zhou, HM, Brust-Mascher, I and Scholey JM (2004) Two Anterograde Intraflagellar Transport Motors Cooperate to Build Sensory Cilia on C. elegans Neurons. Nature Cell Biol. 6(11):1109-13. *co-first authors

4. Ou, G.*, Qin, H.*, Rosenbaum, JL and JM Scholey (2005) The PKD protein qilin undergoes intraflagellar transport. Current Biology. 15(11):R410-1. *co-first authors

5. Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature. 436(7050):583-7.

6. Pan, X. *, Ou, G. *, Civelekoglu-Scholey, G., Blacque, O.E., Endres, N.F., Li, T., Mogilner, A., Leroux, M.R., Vale, R.D. and J.M. Scholey. (2006) Mechanism of transport of IFT-particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. Journal of Cell Biology. 174(7):1035-45. *co-first authors

7. Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, Schafer JC, Li C, Yoder BK, Leroux MR, Scholey JM. (2007) Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Molecular Biology of the Cell. 18(5):1554-69.

8. Inglis PN, Ou G., Leroux MR and Scholey JM. (2007) The sensory cilia of Caenorhabditis elegans. WormBook. 2007 Mar 8:1-22.

9. Ou GS*, Chen ZL*, Yuan M. (2002) Jasplakinolide reversibly disrupts actin filaments in suspension-cultured tobacco BY-2 cells. Protoplasma. 219(3-4):168-75. *co-first authors

研究组工作摘要

Our laboratory aims to understand how cytoskeleton and signaling-related biomacromolecules regulate neural progenitors to divide, migrate, differentiate and die using Caenorhabditis elegans as the model system. Current research on neural development is limited to observations at fixed time points and its dynamic processes are not well documented. Current study on cell dynamics by high resolution live microscopy is being mostly performed in cell lines, but many cell behaviors such as asymmetric cell divisions or directed cell migration cannot be easily mimicked in cultures. Our investigations can provide advanced spatial and temporal resolutions to neural development, as well as new model systems to study cellular events in their native niches. C. elgeans Q neuroblasts (progenitors of sensory neurons and interneurons) are excellent cells to start with because they generate neurons by asymmetric cell divisions, long distance migration, apoptosis and neuritogenesis, all of which are interesting topics in developmental neurobiology. Most importantly, we have recently developed live Q cell time-lapse fluorescence imaging techniques to visualize all of the events by spinning disk confocal microscopy, placing our lab in a unique position for such studies. With the combination of our new live cell microscopy and C. elegans genetics and genomics, we expect to better understand molecular mechanisms of cell dynamics in C. elegans Q neuroblast migration, division and apoptosis.

本课题组发展***荧光时序成像技术并结合生物化学和遗传学，以线虫为模型研究细胞骨架和信号转导蛋白如何调控神经系统的发育。我们选择线虫的Q神经母细胞为研究对象，其发育过程包括不对称分裂、长距离迁移、细胞凋亡及神经丝的形成，最终产生触觉神经元和中间神经元。我们利用转盘碟片激光共聚焦显微镜记录在世界上首次了上述所有发育过程，使得我们处于一个独特的位置去研究如下生物学问题：（1） Q神经母细胞如何进行不对称细胞分裂的？不对称性是如何产生的? 其细胞和分子机制是否类似于已知的不对称分裂？ 或者使用未知的不对称机制？（2） Q神经母细胞的迁移方向和距离及速度是如何决定的？Wnt信号是如何传导到细胞骨架上产生力和运动的？（3）Q神经母细胞发育过程中产生的凋亡细胞是如何进入凋亡程序？最终如何被附近的表皮细胞吞噬的？对于线虫的Q神经母细胞的研究可以加深我们对于神经发育，不对称分裂，细胞迁移和细胞凋亡的认识。 这些生物学过程的异常会导致诸多人类疾病如癌症，因此，从我们的研究中获得的信息有助于我们理解人类疾病的调控机制。