[北京]高毅勤教授研究组招聘

发布时间：2010-08-27
工作地点：北京
信息来源：北京大学化学学院
职位类型：全职
职位描述
北京大学化学与分子工程学院高毅勤研究组招聘博士后研究人员2-3名, 申请人需对科研工作有浓厚的兴趣，具备扎实的研究基础，遵守学术道德规范，有良好的沟通能力，善于与人合作。申请人请提供详细的个人简历、工作经历、工作业绩等，以及2-3封推荐信和推荐人的详细联系方式。

联系人：高毅勤 gaoyq@

研究方向:　生物物理化学；计算与理论化学

(1) 生物酶催化与蛋白质分子机器中的运输机能量转化机制研究

(2) 生物大分子与材料自组装

(3) 生命体系中的限域以及拥挤效应—从试管到细胞的物理化学性质

(4) 蛋白质构象变化的控制与功能—无机盐和糖类、醇类等有机小分子影响蛋白质结构的机理研究

(5) 生物大分子间的相互作用: 蛋白质／蛋白质和蛋白质／细胞膜相互作用以及它们在细胞内信号传递中的功能

代表论文：



1) Effects of Turn Stability and Side Chain Hydrophobicity on the Folding of beta-structures, Q. Shao; H. Wei; Y. Q. Gao, Journal of Molecular Biology, accepted (2010).

2) Mutation of Charged Residues to Neutral Ones Accelerates Urea Denaturation of HP-35, H. Wei, L. Yang, Y.Q. Gao, J. Phys. Chem. B, In Press (2010).

3) The Effects of Side Chain Hydrophobicity and Turn Formation on beta-Structures: Sequence Dependence on Urea Denaturation, H. Wei, Q. Shao, and Y.Q. Gao, Phys. Chem. Chem. Phys. 12, 9292-9299 (2010).

4) Coorperativity between Metals, Ligands and Solvent: a DFT Study on the Mechanism of a Dizinc Complex-Mediated Phosphodiester Cleavage, Y.B. Fan and Y.Q. Gao, Acta Phys. Chim. 26, 1034-1042 (2010).

5) The long range effects of confinement on water structure, Y.B. Fan and Y.Q. Gao, J. Phys. Chem. B, 114, 4246–4251 (2010).

6) The carbamate transport in the tunnel of CPS-a combined theoretical and experimental study, L. Lund, Y. B. Fan, Q. Shao, Y. Q. Gao, and F. Raushel, J. Am. Chem. Soc., 132, 3870–3878 (2010). Highlighted in Nature Chemistry.

7) Effects of Cosolvents on the Hydration of Carbon Nanotubes, L. Yang and Y. Q. Gao J. Am. Chem. Soc., 132, 842–848 (2010).

8) Effects of Urea, Tetramethyl Urea, and Trimethylamine N-Oxide on Aqueous Solution Structure and Solvation of Protein Backbones: A Molecular Dynamics Simulation Study, H. Y Wei, Y. Fan, Y. Q. Gao, J. Phys. Chem. B, 114, 557–568 (2010).

9) Self-assembly of polypeptides into left-handedly twisted fibril-like structures, Y. Mu, Y.Q. Gao,Phys. Rew. E 80, 041927 (2009).

10) A selective integrated tempering method, L.J. Yang, Y.Q. Gao J. Chem. Phys. 131, 214109 (2009).

11) A simple model and assignment of the SFG spectrum for the water/air interface, Y. Fan, X. Chen. P. Cremer, and Y.Q. Gao, J. Phys. Chem. B, 113 11672-11679 (2009).

12) On the Structure Elucidation using IMS and Molecular Dynamics, F. A. Fernandez-Lima, H. Wei, Y. Q. Gao, D. H. Russell, J. Phys. Chem. A 29, 8221-8234 (2009).

13) A combined computational and experimental studies of the ammonia transport in CPS, Y. Fan, L. Lund, Y.Q. Gao, and F. Raushel, J. Am. Chem, Soc. 131, 10211-10219 (2009).

14) A test of implicit solvent models on the folding simulation of the GB1 peptide. Q. Shao, L. Yang, and Y. Q. Gao J. Chem. Phys. 130, 195104 (2009).

15) Free energies and forces in helix–coil transition of homopolypeptides under stretching. F. C. Zegarra, G. N. Peralta, A. M. Coronado and Y. Q. Gao, Phys. Chem. Chem. Phys.11, 4019-4024 (2009).

16) Comparison between integrated and parallel tempering methods in enhanced sampling, L.J. Yang, and Y. Q. Gao, J. Chem. Phys. 130, 124111 (2009).

17) Thermodynamics and folding pathways of trpzip2, L.J.Yang, Q. Shao, and Y. Q. Gao, J. Phys. Chem. B, 113, 803-808 (2009).

18) Chemomechanical coupling of kinesin and dynein, in Proteins: Energy, Heat and Signal Flow, Taylor & Francis Group (2009).

19) Enhanced sampling methods for thermodynamics and kinetics simulations, Y.Q. Gao, L.J. Yang, Y. Fan, and Q. Shao, International Review in Physical Chemistry, 27, 201-227 (2008). Cover paper.

20) Self-adaptive enhanced sampling in the energy and trajectory spaces: Accelerated thermodynamics and kinetic calculations, Y.Q. Gao, J. Chem. Phys. 128, 134111 (2008).

21) An integrate-over-temperature approach for the enhanced sampling in molecular dynamics simulations, Y.Q. Gao, J. Chem. Phys. 128, 064105 (2008).

22) A molecular dynamics simulation study of ammonia transport in CPS, Y. Fan, L. Lund, L. J. Yang, F. Raushel, and Y.Q. Gao, Biochemistry, 47, 2935-2944 (2008).

23) An approximate theory for the ozone isotopic effect, Y.Q. Gao and R.A. Marcus, J. Chem. Phys. 127, 244316 (2007).

24) Selective sampling of transition paths, X. Fu, L, Yang, and Y.Q. Gao, J. Chem. Phys. 127, 154106 (2007).

25) Asymmetry in kinesin walking, Q. Shao and Y.Q. Gao, Biochemistry, 46, 9098-9106 (2007).

26) The effects of hydrophobic and dipole-dipole interactions on the conformational transitions between different model polypeptide structures, Y. Mu and Y. Q. Gao, J. Chem. Phys. 127, 105102 (2007).

27) A DFT study on the mechanism of phosphodiester cleavage mediated by monozinc complexes, Y. Fan and Y.Q. Gao, J. Am. Chem. Soc. 129, 895-904 (2007).

28) Application of the accelerated MD simulations to the folding of a small protein, L. Yang, M. P. Grubb, and Y. Q. Gao, J. Chem. Phys. 126, 125102 (2007).

29) An approximate method for the MD simulations of protein conformational changes, L. Yang and Y. Q. Gao, J. Phys. Chem. B 111, 2969-2975 (2007).

30) A kinetic model for myosin V, Y.D. Wu, Y.Q. Gao, and M. Karplus, Biochemistry, 46, 6318-6330 (2007).

31) On the enhanced sampling over energy barriers in molecular dynamics simulations, Y.Q. Gao and L. Yang, J. Chem. Phys. 125, 114103 (2006).

32) On the hand-over-hand mechanism of kinesin, Q. Shao and Y.Q. Gao, Proc. Natl. Acad. Sci. (USA), 103, 8072-8077 (2006).

33) Thermodynamics and kinetic analysis of F1Fo-ATP synthase, Y. Q. Gao, W. Yang, and M. Karplus, in Modern computational method of biopolymers (Elsevier, 2006).

34) A simple theoretical model explains dynein’s response to external load, Y.Q. Gao, Biophys. J. 90, 811-821 (2006).

35) The binding change mechanism of F1-ATPase revisited, Y. Q. Gao, W. Yang, and M. Karplus, Cell 123, 195-205 (2005).

36) A model for the cooperativity in the free energy transduction and kinetics in ATP hydrolysis by F1-ATPase, Y. Q. Gao, W. Yang, R. A. Marcus, and M. Karplus, Proc. Natl. Acad. Sci. (USA) 100, 11339-11345 (2003).

37) The missing link between thermodynamics and structure in F1-ATPase, W. Yang, Y. Q. Gao, Q. Cui, J. Ma, and M. Karplus, Proc. Natl. Acad. Sci. (USA) 100, 874-879 (2003).

38) Strange and unconventional isotopic effect in ozone formation, Y. Q. Gao and R. A. Marcus, Science 293, 259 (2001).